Sulfo-ara-F-NMN (Synonyms: CZ-48) |
| رقم الكتالوجGC61803 |
Sulfo-ara-F-NMN (CZ-48) هو مقلد للنيكوتيناميد أحادي نيوكليوتيد (NMN)
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Cas No.: 1374663-29-2
Sample solution is provided at 25 µL, 10mM.
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Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].
[1]. Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.
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