SW203668 (trifluoroacetate salt) |
| رقم الكتالوجGC44975 |
SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2117405-48-6
Sample solution is provided at 25 µL, 10mM.
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SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.
Average Rating: 5 (Based on Reviews and 37 reference(s) in Google Scholar.)
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