Synucleozid (Synonyms: NSC 377363) |
| カタログ番号GC39510 |
シヌクレオジド（NSC 377363）は、α-シヌクレインタンパク質をエンコードするSNCA mRNAの強力な阻害剤です（IC50 = 1.5μM）。
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Cas No.: 502139-01-7
Sample solution is provided at 25 µL, 10mM.
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Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1].
[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
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