Synucleozid (Synonyms: NSC 377363) |
| Catalog No.GC39510 |
Synucleozid (NSC 377363) es un potente inhibidor del ARNm SNCA que codifica la proteína α-sinucleína (IC50=1.5 μM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 502139-01-7
Sample solution is provided at 25 µL, 10mM.
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Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein (IC50=1.5 μM). Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson's disease[1].
[1]. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
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