Talampanel (Synonyms: GYKI 53773, LY 300164) |
| رقم الكتالوجGC19346 |
Talampanel (LY300164) هو مضاد لمستقبلات ألفا-أمينو-3-هيدروكسي-5-ميثيل-4-إيزوكسازوليبروبيونات (AMPA) عن طريق الفم والانتقائية مع نشاط مضاد للتشنج
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Cas No.: 161832-65-1
Sample solution is provided at 25 µL, 10mM.
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Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Target: AMPA [1]in vitro: Talampanel is a glutamate receptor inhibitor with anti-seizure activity.in vivo: Talampanel reduces motoneuronal calcium in a mouse model of ALS, but its effi cacy declines as the disease progresses, suggesting that medication initiation in the earlier stages of the disease might be more effective. [2]
References:
[1]. Langan YM, et al. Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy. Epilepsia. 2003 Jan;44(1):46-53.
[2]. Paizs M, et al. Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically. Amyotroph Lateral Scler. 2011 Sep;12(5):340-344.
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