TC KHNS 11 |
| رقم الكتالوجGC50332 |
Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1431540-99-6
Sample solution is provided at 25 µL, 10mM.
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Potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.
Hoegenauer et al (2016) Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 7 762 PMID:27563400
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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