Tenidap (Synonyms: CP 66,248) |
| رقم الكتالوجGC11853 |
Tenidap ، دواء مضاد للالتهابات غير ستيرويدي ، هو مثبط انتقائي لـ COX-1 ، بقيم IC50 تبلغ 0.03 ميكرومتر و 1.2 ميكرومتر لـ COX-1 و COX-2 ، على التوالي
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Cas No.: 120210-48-2
Sample solution is provided at 25 µL, 10mM.
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Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor.
References:
[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.
[2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56.
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