THZ-P1-2 |
| رقم الكتالوجGC39823 |
THZ-P1-2 هو مثبط PI5P4K الأول في فئته وانتقائي ، مع IC50 من 190 نانومتر لـ PI5P4Kαيستهدف THZ-P1-2 بشكل تساهمي السيستين على حلقة مضطربة في PI5P4Kα / β / γيسبب THZ-P1-2 اضطراب الالتهام الذاتي وينظم إشارات TFEBيعرض THZ-P1-2 نشاطًا مضادًا للسرطان في خطوط خلايا سرطان الدم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2058075-45-7
Sample solution is provided at 25 µL, 10mM.
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THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
[1]. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6.
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