THZ-P1-2 |
| Catalog No.GC39823 |
THZ-P1-2는 PI5P4Kα에 대한 IC50이 190nM인 동급 최초의 선택적 PI5P4K 억제제입니다. THZ-P1-2는 PI5P4Kα/β/γ의 무질서한 루프에 있는 시스테인을 공유적으로 표적화합니다. THZ-P1-2는 자가포식 교란을 일으키고 TFEB 신호전달을 상향 조절합니다. THZ-P1-2는 백혈병 세포주에서 항암 활성을 나타냅니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2058075-45-7
Sample solution is provided at 25 µL, 10mM.
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THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
[1]. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6.
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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