THZ-P1-2 |
| Catalog No.GC39823 |
THZ-P1-2 est un inhibiteur sélectif de PI5P4K, premier de sa classe, avec une IC50 de 190 nM pour PI5P4Kα. THZ-P1-2 cible de manière covalente les cystéines sur une boucle désordonnée dans PI5P4Kα/β/γ. THZ-P1-2 provoque une perturbation de l'autophagie et régule positivement la signalisation TFEB. THZ-P1-2 affiche une activité anticancéreuse dans les lignées cellulaires leucémiques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2058075-45-7
Sample solution is provided at 25 µL, 10mM.
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THZ-P1-2 is a first-in-class and selective PI5P4K inhibitor, with an IC50 of 190 nM for PI5P4Kα. THZ-P1-2 covalently targets cysteines on a disordered loop in PI5P4Kα/β/γ. THZ-P1-2 causes autophagy disruption and upregulates TFEB signaling. THZ-P1-2 displays anticancer activity in leukemia cell lines[1].
[1]. Sivakumaren SC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chem Biol. 2020;27(5):525‐537.e6.
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