UCSF924 |
| رقم الكتالوجGC61364 |
UCSF924 عبارة عن ناهض جزئي لمستقبلات الدوبامين D4 (DRD4) القوية والمحددة مع EC50 من 4.2 نانومتر
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Cas No.: 1434515-70-4
Sample solution is provided at 25 µL, 10mM.
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UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1].
[1]. Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386.
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