UK-371804 |
| Catalog No.GC31716 |
UK-371804는 Ki가 10nM인 유로키나제형 플라스미노겐 활성제(uPA) 억제제입니다.
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Cas No.: 256477-09-5
Sample solution is provided at 25 µL, 10mM.
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UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin)[1].
In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM[1].
[1]. Fish PV, et al. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51.
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