Verdiperstat (AZD3241) (Synonyms: AZD3241) |
| رقم الكتالوجGC30237 |
Verdiperstat (AZD3241) (AZD3241) هو مثبط انتقائي ، لا رجعة فيه ونشط عن طريق الفم (MPO) ، مع IC50 من 630 نانومتر ، ويمكن استخدامه في البحث عن اضطرابات الدماغ التنكسية العصبية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 890655-80-8
Sample solution is provided at 25 µL, 10mM.
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Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders[1]. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation[2].
[1]. Johnstr?m P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. [2]. Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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