Verdiperstat (AZD3241) (Synonyms: AZD3241) |
| Catalog No.GC30237 |
Le verdiperstat (AZD3241) (AZD3241) est un inhibiteur de la myéloperoxydase (MPO) sélectif, irréversible et actif par voie orale, avec une IC50 de 630 nM, et peut être utilisé dans la recherche sur les troubles cérébraux neurodégénératifs.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 890655-80-8
Sample solution is provided at 25 µL, 10mM.
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Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
Verdiperstat (AZD3241) is a myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and is used in the research of neurodegenerative brain disorders[1]. Verdiperstat (AZD3241) selectively and irreversibly inhibits myeloperoxidase, and may involves reduction of oxidative stress leading to reduction of sustained neuroinflammation[2].
[1]. Johnstr?m P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42(6):555-60. [2]. Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138(Pt 9):2687-700.
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