VPC-70619 |
| رقم الكتالوجGC64562 |
VPC-70619 هو أحد مثبطات N-Myc الفعالة عن طريق الفميمنع VPC-70619 مركب N-Myc-Max غير المتجانسة من الارتباط بصناديق الحمض النووي الإلكترونية ويظهر نشاط تثبيط قوي ضد خطوط الخلايا المعتمدة على N-Myc بالإضافة إلى التوافر البيولوجي العالي في كل من الإعطاء الفموي وداخل الصفاق
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361742-30-3
Sample solution is provided at 25 µL, 10mM.
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VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration[1].
[1]. Ton AT, et al. Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer. Int J Mol Sci. 2022;23(5):2588. Published 2022 Feb 26.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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