VPC-70619 |
| カタログ番号GC64562 |
VPC-70619 は、強力な経口活性 N-Myc 阻害剤です。 VPC-70619 は、N-Myc-Max ヘテロ複合体が DNA E-box に結合するのをブロックし、N-Myc 依存性細胞株に対する強力な阻害活性と、経口および腹腔内投与の両方で高いバイオアベイラビリティを示しました。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361742-30-3
Sample solution is provided at 25 µL, 10mM.
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VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration[1].
[1]. Ton AT, et al. Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer. Int J Mol Sci. 2022;23(5):2588. Published 2022 Feb 26.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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