VPC-70619 |
Catalog No.GC64562 |
Le VPC-70619 est un puissant inhibiteur de N-Myc actif par voie orale. Le VPC-70619 empêche l'hétérocomplexe N-Myc-Max de se lier aux boÎtes E de l'ADN et a démontré une forte activité d'inhibition contre les lignées cellulaires dépendantes de N-Myc ainsi qu'une biodisponibilité élevée en administration orale et intrapéritonéale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361742-30-3
Sample solution is provided at 25 µL, 10mM.
VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration[1].
[1]. Ton AT, et al. Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer. Int J Mol Sci. 2022;23(5):2588. Published 2022 Feb 26.
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