XL177A |
| رقم الكتالوجGC62517 |
XL177A هو مثبط USP7 قوي للغاية وانتقائي لا رجعة فيه مع IC50 من 0.34 نانومتريتسبب XL177A في قتل الخلايا السرطانية من خلال آلية تعتمد على p53
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2417089-74-6
Sample solution is provided at 25 µL, 10mM.
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XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell killing through a p53-dependent mechanism[1].
XL177A is a potent USP7 inhibitor and p53 stabilizer in cyto. XL177A suppresses cancer cell growth predominantly through a p53-dependent mechanism. XL177A labels the catalytic cysteine, C223, of USP7 with exquisite selectivity for USP7 across the DUBome and human proteome[1]. XL177A (1 μM) induces complete G1 arrest in MCF7 cells after 24 hours[1].Treatment of MCF7 cells, which express WT TP53, with XL177A (0.001- 10 μM) induces rapid degradation of HDM2 within 2 hours, followed by increases in p53 and downstream p21 protein levels[1].
[1]. Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.
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