XL177A |
| カタログ番号GC62517 |
XL177A は、IC50 が 0.34nM の非常に強力で選択的な不可逆的な USP7 阻害剤です。 XL177A は、p53 依存性メカニズムを介して癌細胞の殺傷を誘発します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2417089-74-6
Sample solution is provided at 25 µL, 10mM.
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XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM. XL177A elicits cancer cell killing through a p53-dependent mechanism[1].
XL177A is a potent USP7 inhibitor and p53 stabilizer in cyto. XL177A suppresses cancer cell growth predominantly through a p53-dependent mechanism. XL177A labels the catalytic cysteine, C223, of USP7 with exquisite selectivity for USP7 across the DUBome and human proteome[1]. XL177A (1 μM) induces complete G1 arrest in MCF7 cells after 24 hours[1].Treatment of MCF7 cells, which express WT TP53, with XL177A (0.001- 10 μM) induces rapid degradation of HDM2 within 2 hours, followed by increases in p53 and downstream p21 protein levels[1].
[1]. Nathan J Schauer, et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci Rep.2020 Mar 24;10(1):5324.
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