DNA Damage/DNA Repair

NERx 329 is a replication protein A ( RPA ) inhibitor with an IC 50 of 4.9 μM.

Tofersen scrambled control is a scrambled control antisense oligonucleotide of Tofersen with a scrambled sequence in the target binding region.

ASO 556089 (with PS modification) sodium is the PS-modified version of ASO 556089.

HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC 50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively.

HDAC6-IN-75 is a selective HDAC6 inhibitor with an IC 50 of 0.17 nM against HDAC6.

HDAC1/3-IN-1 is a selective HDAC1/3 inhibitor, with IC 50 values of 256 nM and 340.3 nM against HDAC1 and HDAC3, respectively.

CG-1521 is a histone deacetylase ( HDAC ) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation.

OUL312 is a potent PARP10 inhibitor ( IC 50 = 20 nM), showing more than 75-fold greater selectivity for PARP15 ( IC 50 = 1500 nM).

HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC 50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively.

G194-0712 is a selective histone deacetylase 5 ( HDAC5 ) activator with an EC 50 of 7.96 μM and a K d of 2.53 μM.

PTERi is a selective inhibitor of PTER with selectivity towards HDACs.

HDAC11-IN-4 is a potent and selective HDAC11 inhibitor with an IC 50 of 13.49 nM and a K i of 2.2 nM.

KMR-206 is a PARP7 inhibitor with an IC 50 of 13.7 nM.

PARP1/NAMPT-IN-1 is a potent and dual PARP1 and NAMPT inhibitor with IC 50 values of 1.2 nM and 6.7 nM, respectively.

SAP15 (Synthetic anti-inflammatory peptide 15) acetate is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3.

A-620223 is a PARP-1 inhibitor with a K i of 8 nM against PARP-1 and EC 50 of 3 nM in a whole cell assay.

PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP−ribose) polymerase ( PARP1 ) inhibitor.

PCIP-1 is a PARP2 inhibitor.

TNKS-IN-1 is a selective and potent tankyrase ( TNKS1 / TNKS2 ) inhibitor with IC 50 values of 7.9 nM and 8.7 nM.

VT00065 is a covalent DHS inhibitor.

NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter.

APL-4098 is an orally active, selective, ATP-competitive GCN2 inhibitor with a K i of 4.39 nM and a K d of 2.9 nM.

ADAR1i-124 is an A-to-I RNA editing inhibitor by inhibiting the catalytic activities of both ADAR1p150 and ADAR1p110.