3,4,5-Trimethoxycinnamic acid |
| Catalog No.GC33703 |
El Ácido 3,4,5-trimetoxicinÁmico es un fenilpropanoide aislado de las raÍces de Polygala tenuifoliaWILLD, con efecto antiestrés, prolongando el tiempo de sueÑo en los animales.
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Cas No.: 90-50-6 ; 20329-98-0
Sample solution is provided at 25 µL, 10mM.
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3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals[1][2]. 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
3,4,5-Trimethoxycinnamic acid (10 μg/ml) increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits[2].
3,4,5-Trimethoxycinnamic acid (25-100 mg/kg, i.p.) exhibits sedative effect, and prolongs the sleeping time in rats[1].3,4,5-Trimethoxycinnamic acid (10 mg/kg, p.o.) significantly decreases locomotor activity in mice[2].
[1]. Kawashima K, et al. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull. 2004 Aug;27(8):1317-9. [2]. Lee CI, et al. 3,4,5-Trimethoxycinnamic acid (TMCA), one of the constituents of Polygalae Radix enhances pentobarbital-induced sleeping behaviors via GABAAergic systems in mice. Arch Pharm Res. 2013 Oct;36(10):1244-51.
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