5-ALA benzyl ester hydrochloride |
| Catalog No.GC38882 |
El clorhidrato de éster bencÍlico de 5-ALA (clorhidrato de bencil-ALA) es un precursor de protoporfirina que se utiliza como agente de fotodetecciÓn. El clorhidrato de éster bencÍlico de 5-ALA induce la acumulaciÓn de protoporfirina IX (PPIX) en lÍneas celulares de carcinoma de colon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 163271-32-7
Sample solution is provided at 25 µL, 10mM.
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5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor used as a photodetection agent. 5-ALA benzyl ester hydrochloride induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines[1][2].
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480[2].
Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels[3]. Animal Model: Female CBA/Gy mouse (CaNT tumour model)[3]
[1]. Hirschberg H, et al. ALA- and ALA-ester-mediated photodynamic therapy of human glioma spheroids. J Neurooncol. 2002 Mar;57(1):1-7. [2]. Brunner H, et al. The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 Nov;74(5):721-5. [3]. Tunstall RG, et al. Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo. Br J Cancer. 2002 Jul 15;87(2):246-50.
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