8-iso Prostaglandin F2α (Synonyms: iPF2α-III, 8-iso-15(S)-Prostaglandin F2α, 8-Isoprostane, 8-epi PGF2α, 15-F2t-Isoprostane) |
| Catalog No.GC18515 |
La 8-iso prostaglandina F2α es un isoprostano producido por la peroxidación no enzimática del ácido araquidónico en los fosfolípidos de membrana.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27415-26-5
Sample solution is provided at 25 µL, 10mM.
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8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.
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