8-iso Prostaglandin F2α (Synonyms: iPF2α-III, 8-iso-15(S)-Prostaglandin F2α, 8-Isoprostane, 8-epi PGF2α, 15-F2t-Isoprostane) |
| Catalog No.GC18515 |
8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 27415-26-5
Sample solution is provided at 25 µL, 10mM.
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8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-46619 (10-6 M) and I-BOP (3 x 10-7 M) with IC50 values of 1.6 x 10-6 M and 1.8 x 10-6 M, respectively.
Review for 8-iso Prostaglandin F2α
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
Review for 8-iso Prostaglandin F2α
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