A 1899 |
| Catalog No.GC50632 |
Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 498577-46-1
Sample solution is provided at 25 µL, 10mM.
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Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) channel blocker (IC50 values are 7 nM and 70 nM for human TASK-1 and TASK-3 expressed in CHO cells, respectively). Displays >12.5-fold selectivity for TASK-1 and TASK-3 over other K+ channels (IC50 = 0.9 μM for K2P18.1/TRESK and >2 μM for all other channels tested). Binds within open channel pore.
Streit et al (2011) A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J.Biol.Chem. 286 13977 PMID:21362619
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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