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A23187 (calcium magnesium salt) (Synonyms: Calcimycin)

Catalog No.GC42659

A23187 is a divalent cation ionophore.

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A23187 (calcium magnesium salt) Chemical Structure

Tamaño Precio Disponibilidad Cantidad
1mg
43,00 $
Disponible
5mg
97,00 $
Disponible
10mg
171,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Chemical Properties Product Documents Related Products

A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.[1] A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.[2],[3]

Reference:
[1]. Sullivan, T.J., and Parker, C.W. Pharmacologic modulation of inflammatory mediator release by rat mast cells. Am. J. Pathol. 85(2), 437-464 (1976).
[2]. Maecker, H.T., Hedjbeli, S., Alzona, M., et al. Comparison of apoptosis signaling through T cell receptor, Fas, and calcium ionophore. Exp. Cell Res. 222(1), 95-102 (1996).
[3]. Cho, S.Y., Lee, J.H., Bae, H.D., et al. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp. Mol. Med. 42(9), 639-650 (2010).

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