Balovaptan (RG7314) (Synonyms: RG7314) |
Catalog No.GC31295 |
Balovaptan (RG7314) es un antagonista selectivo del receptor de vasopresina 1a (hV1a), disponible por vía oral y que penetra en el cerebro, con Kis de 1 y 39 nM para los receptores humanos (hV1a) y de ratón (mV1a), utilizado para la investigación del autismo.
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Cas No.: 1228088-30-9
Sample solution is provided at 25 µL, 10mM.
Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].
[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.
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