Balovaptan (RG7314) (Synonyms: RG7314) |
| Catalog No.GC31295 |
발로밥탄 (RG7314)은 구강 투여 가능한 선택적 뇌 침투성 혈관수축호르몬 1a (hV1a) 수용체 억제제입니다. 인간(hV1a) 및 마우스(mV1a) 수용체에 대한 Ki 값은 각각 1nM과 39nM이며, 자폐증 연구에 사용됩니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1228088-30-9
Sample solution is provided at 25 µL, 10mM.
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Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.
Balovaptan is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a, and is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].
[1]. Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58(5):2275-89.
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