Basiliximab (Synonyms: CHI 621) |
Catalog No.GC66331 |
Basiliximab (CHI 621) es un anticuerpo anti-receptor de interleucina-2 monoclonal murino/humano IgG1 recombinante quimérico. Basiliximab se puede utilizar para la investigaciÓn del trasplante renal.
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Cas No.: 179045-86-4
Sample solution is provided at 25 µL, 10mM.
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation[1].
Basiliximab specifically inhibits T lymphocyte proliferation by binding to the IL-2Rα[1].
Basiliximab binds only to activated lymphocytes and macrophages/monocytes[3].
Basiliximab does not affect resting T lymphocytes that do not express IL-2Rα[3].
Basiliximab (CHI 621) (0.07 mg/rat; i.v.; once) decreases total placental natural killer cells in reduced uterine perfusion pressure (RUPP) rats[2].
Animal Model: | Timed-pregnant Sprague Dawley (SD) rats, reduced uterine perfusion pressure (RUPP) rat model of placental ischemia[2] |
Dosage: | 0.07 mg/rat |
Administration: | IV infusion, once |
Result: | Decreased total placental natural killer cells. Had no effect to lower MAP or improve pup weight and placental weight. |
Average Rating: 5
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