Beclabuvir (BMS-791325) (Synonyms: BMS-791325) |
| Catalog No.GC33925 |
Beclabuvir (BMS-791325) es un inhibidor alostérico que se une al sitio 1 del pulgar de la ARN polimerasa dependiente de ARN NS5B del virus de la hepatitis C (VHC) e inhibe las proteÍnas NS5B recombinantes de los genotipos 1, 3, 4 y 5 del VHC con IC50 de < 28 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 958002-33-0
Sample solution is provided at 25 µL, 10mM.
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Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
Beclabuvir demonstrates additive or synergistic antiviral activity with pegIFN/RBV and in 2- or 3-drug combinations with a range of DAAs, such as HCV NS3 protease inhibitors, NS5A inhibitors' and/or nucleoside NS5B inhibitors[2].
The combination of beclabuvir with asunaprevir and daclatasvir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide[1].
[1]. Gentile I, et al. Beclabuvir for the treatment of hepatitis C. Expert Opin Investig Drugs. 2015;24(8):1111-21. [2]. Tatum H, et al. A randomized, placebo-controlled study of the NS5B inhibitor beclabuvir with peginterferon/ribavirin for HCV genotype 1. J Viral Hepat. 2015 Aug;22(8):658-64.
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