BIBX 1382 dihydrochloride |
| Catalog No.GC50026 |
Highly selective EGFR-kinase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1216920-18-1
Sample solution is provided at 25 µL, 10mM.
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Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). Oral administration inhibits growth of established human xenografts in athymic mice.
Dittrich et al (2002) Phase I and pharmacokinetic study of BIBX1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration. Eur.J.Cancer 38 1072 PMID:12008195 |Solca et al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502 PMID:15199094
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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