BIX NHE1 inhibitor |
Catalog No.GC50659 |
El inhibidor BIX NHE1 es un potente inhibidor de la isoforma 1 del intercambiador de sodio-hidrÓgeno (NHE1), con IC50 de 6 y 31 nM en ensayos de recuperaciÓn del pH intracelular (pHi) y de hinchazÓn de plaquetas humanas, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1422252-46-7
Sample solution is provided at 25 µL, 10mM.
Potent and selective NHE1 inhibitor (IC50 = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.
Average Rating: 5
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