BLU-554 (Synonyms: BLU-554) |
| Catalog No.GC19075 |
BLU-554 (BLU-554) es un inhibidor potente, altamente selectivo y activo por vÍa oral del receptor 4 del factor de crecimiento de fibroblastos (FGFR4) con una IC50 de 5 nM. BLU-554 tiene una actividad antitumoral significativa en modelos de carcinoma hepatocelular (CHC) que dependen de la seÑalizaciÓn de FGFR4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1707289-21-1
Sample solution is provided at 25 µL, 10mM.
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BLU-554 is a potent fibroblast growth factor receptor 4 (FGFR4) inhibitor.
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR-4 gene. This protein is a member of the fibroblast growth factor receptor family, where amino acid sequence was highly conserved between members throughout evolution. FGFR family members 1-4 differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of the FGFR-4 gene encompasses 18 exons. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the Iglll domain of this protein varies between three alternate forms, as indicated for FGFR 1-3[1].
References:
[1]. Neil Bifulco, et al. Inhibitors of the fibroblast growth factor receptor. PCT Int. Appl. (2015), WO 2015061572 A1 20150430.
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