Boc-NH-PEG2-CH2COOH |
| Catalog No.GC60653 |
HBC514 es un anÁlogo de HBC no fluorescente, pero emite una fuerte fluorescencia verde al formar un complejo compacto con el aptÁmero de ARN de Pepper. El complejo HBC514-Pepper permite la visualizaciÓn de ARN y las fluorescencias se pueden alterar de forma flexible mediante un simple lavado y tinciÓn en células vivas marcadas con Pepper.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108466-89-3
Sample solution is provided at 25 µL, 10mM.
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Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020 Feb 1;187:111952.
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