BTS (Synonyms: N-Benzyl-p-toluenesulfonamide, NSC 37123) |
| Catalog No.GC16189 |
BTS (N-bencil-p-toluenosulfonamida) es un inhibidor potente y selectivo de la actividad ATPasa del subfragmento 1 (S1) de la miosina II del mÚsculo esquelético, con una IC50 de ~5 μM para la miosina S1 ATPasa estimulada por actina y Ca2+-.
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Cas No.: 1576-37-0
Sample solution is provided at 25 µL, 10mM.
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BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
References:
[1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.
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