SMAP-2 (Synonyms: DT-1154) |
| Catalog No.GC39440 |
SMAP-2 (DT-1154) es un activador de la proteÍna fosfatasa 2A (PP2A) activo por vÍa oral, con actividad anticancerÍgena.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1809068-70-9
Sample solution is provided at 25 µL, 10mM.
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SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. SMAP-2 (DT-1154) inhibits the growth of KRAS-mutant lung cancers [1].
[1]. Sangodkar J, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017 Jun 1;127(6):2081-2090.
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