Tribenoside

Name: Tribenoside
Brand: GlpBio
SKU: GC49072
Availability: InStock
Rating: 5 (7 reviews)

Catalog No.GC49072

Tribenoside es un agente vasoprotector, se puede utilizar para la investigaciÓn de las hemorroides.

Products are for research use only. Not for human use. We do not sell to patients.

Tribenoside Chemical Structure

Cas No.: 10310-32-4

Tamaño

Precio

Disponibilidad

Cantidad

50 mg	49,00 $	Disponible
100 mg	90,00 $	Disponible
250 mg	199,00 $	Disponible
500 mg	374,00 $	Disponible

Tel：(909) 407-4943 Email: sales@glpbio.com

Reseñas de cliente

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

View current batch:

Purity: >95.00%

Tribenoside is a vasoprotective agent with anti-allergic and anti-inflammatory activities.^1,2 It inhibits agonist-induced contractions in various isolated porcine venous preparations when used at concentrations ranging from 10 to 30 µg/ml.¹ Tribenoside inhibits compound 48/80-induced histamine release in isolated rat peritoneal cells (EC₅₀ = 10 µg/ml).³ It reduces decreases in proteoglycan levels and the severity of cartilage destruction in the inflamed joints in a rabbit model of surgically induced osteoarthritis when administered at doses of 100 and 200 mg/kg per day.⁴ Formulations containing tribenoside have been used in the treatment of hemorrhoids and varicose veins.

1.Jaques, R.The activity pattern, in isolated veins, of a benzyl glucofuranoside derivative possessing combined anti-inflammatory and venotropic effectsPharmacology4(4)193-202(1970) 2.Jaques, R.The pharmacological activity of tribenosidePharmacology15(5)445-460(1977) 3.RÜegg, M., and Jaques, R.Tribenoside as an inhibitor of chemically induced histamine releaseExperientia30(4)399-401(1974) 4.Colombo, C., Butler, M., Hickman, L., et al.A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemicallyArthritis Rheum.26(9)1132-1139(1983)

Cas No.	10310-32-4	SDF
Canonical SMILES	O[C@H]([C@H]1OCC2=CC=CC=C2)C(OCC)O[C@]1([H])[C@@H](COCC3=CC=CC=C3)OCC4=CC=CC=C4
Formula	C29H34O6	M.Wt	478.6
Solubility	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	2.0894 mL	10.4471 mL	20.8943 mL
	5 mM	0.4179 mL	2.0894 mL	4.1789 mL
	10 mM	0.2089 mL	1.0447 mL	2.0894 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal:μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 7 reference(s) in Google Scholar.)

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Tribenoside

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