GSK-A1

Name: GSK-A1
Brand: GlpBio
SKU: GC49284
Availability: InStock
Rating: 5 (14 reviews)

Catalog No.GC49284

GSK-A1 es un inhibidor selectivo de la fosfatidilinositol 4-cinasa PI4KA (PI4KIIIα) de tipo III con una pIC50 de 8,5-9,8.

Products are for research use only. Not for human use. We do not sell to patients.

GSK-A1 Chemical Structure

Cas No.: 1416334-69-4

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Precio

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Cantidad

1 mg	42,00 $	Disponible
5 mg	156,00 $	Disponible
10 mg	292,00 $	Disponible

Tel：(909) 407-4943 Email: sales@glpbio.com

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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Int J Biol Sci 18.13 (2022): 4963.PMID:35982909

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >98.00%

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC₅₀ = 3.16 nM).¹ It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC₅₀s = >50 nM) but also inhibits PI3Kγ (IC₅₀ = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P₁) but not PtdIns-(4,5)-P₂ in HEK293 cells expressing the angiotensin II type 1 (AT₁) receptor (IC₅₀ = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)

Cas No.	1416334-69-4	SDF
Canonical SMILES	O=S(NC1=C(F)C=CC=C1)(C2=C(OC)N=CC(C3=CC4=C(N=C(N4C5=CC=C(N6CCOCC6)C=C5)N)C=C3)=C2)=O
Formula	C29H27FN6O4S	M.Wt	574.6
Solubility	DMSO: 2 mg/ml	Storage	Store at -20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	1.7403 mL	8.7017 mL	17.4034 mL
	5 mM	0.3481 mL	1.7403 mL	3.4807 mL
	10 mM	0.174 mL	0.8702 mL	1.7403 mL

Molarity Calculator
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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal:μL

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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GSK-A1

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