Triptolide-d3 (Synonyms: PG490-d3)

Triptolide-d₃ is intended for use as an internal standard for the quantification of triptolide by GC- or LC-MS. Triptolide is a diterpenoid triepoxide that has been found in T. wilfordii and has diverse biological activities.^1,2,3,4 It inhibits dCTP pyrophosphatase 1 (K_i = 168 µM), an enzyme that prevents halogenated nucleotides from entering DNA synthesis.¹ It reduces viability of A549, H1299, NCI H520, NCI H1650, and H1975 human non-small cell lung cancer (NSCLC) cells when used at a concentration of 50 nM.² Intranasal administration of liposomes containing triptolide (0.4 mg/kg) reduces tumor growth in a rat orthotopic model of lung cancer. Triptolide (0.2 mg/kg) reduces intestinal inflammation and prevents colon shortening in a mouse model of ulcerative colitis induced by dextran sulfate .³ It also inhibits skin allograft rejection and increases graft survival time in mice when administered at a dose of 0.1 mg/kg per day post-transplantation.⁴

1.Corson, T.W., Cavga, H., Aberle, N., et al.Triptolide directly inhibits dCTP pyrophosphataseChemBioChem12(11)1767-1773(2011) 2.Song, J.M., Molla, K., Anandharaj, A., et al.Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signalingOncotarget.8(16)26927-26940(2017) 3.Tang, B., Zhu, J., Zhang, B., et al.Therapeutic potential of triptolide as an anti-inflammatory agent in dextran sulfate sodium-induced murine experimental colitisFront. Immunol.11592084(2020) 4.Yang, S.-X., Gao, H.-L., Xie, S.-S., et al.Immunosuppression of triptolide and its effect on skin allograft survivalInt. J. Immunopharmacol.14(6)963-969(1992)