Benoxaprofen (Synonyms: LRCL 3794, NSC 299582)

Benoxaprofen is a non-steroidal anti-inflammatory drug.¹ It inhibits prostaglandin E₂ and leukotriene C₄ production in isolated mouse peritoneal macrophages stimulated with A23187 when used at a concentration of 100 µM.² Benoxaprofen (25 and 50 µg/ml) inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes.³ It induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner when used at a concentration of 10 µM.⁴ Benoxaprofen reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice in a dose-dependent manner.¹ Formulations containing benoxaprofen have previously been used in the treatment of osteoarthritis and rheumatoid arthritis.

1.Cashin, C.H., Dawson, W., and Kitchen, E.A.The pharmacology of benoxaprofen (2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinflammatory activity apparently unrelated to inhibition of prostaglandin synthesisJ. Pharm. Pharmacol.29(6)330-336(1977) 2.Brune, K., Aehringhaus, U., and Peskar, B.A.Pharmacological control of leukotriene and prostaglandin production from mouse peritoneal macrophagesAgents Actions14(5-6)729-734(1984) 3.Meacock, S.C., and Kitchen, E.A.Effects of the non-steroidal anti-inflammatory drug benoxaprofen on leucocyte migrationJ. Pharm. Pharmacol.31(6)366-370(1979) 4.Sik, R.H., Paschall, C.S., and Chignell, C.F.The phototoxic effect of benoxaprofen and its analogs on human erythrocytes and rat peritoneal mast cellsPhotochem. Photobiol.38(4)411-415(1983)