CAY10580 |
| Catalog No.GC18814 |
CAY10580 es un potente y selectivo agonista del receptor de prostaglandina EP4 (Ki = 35 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64054-40-6
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.
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Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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