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CAY10580

Catalog No.GC18814 Copy One-Click Copy Product Info

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4.

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CAY10580 Chemical Structure

Cas No.: 64054-40-6

Size Price Stock Qty
500μg
$109.00
In stock
1mg
$206.00
In stock
5mg
$853.00
In stock
10mg
$1,491.00
In stock

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Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of CAY10580

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.

Chemical Properties of CAY10580

Cas No. 64054-40-6 SDF
Chemical Name 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
Canonical SMILES CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O
Formula C19H35NO4 M.Wt 341.5
Solubility DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 2.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CAY10580

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.9283 mL 14.6413 mL 29.2826 mL
5 mM 585.7 μL 2.9283 mL 5.8565 mL
10 mM 292.8 μL 1.4641 mL 2.9283 mL
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In vivo Formulation Calculator (Clear solution) of CAY10580

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Reviews

Review for CAY10580

Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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