Cimlanod (Synonyms: BMS-986231; CXL-1427) |
| Catalog No.GC39360 |
Cimlanod (BMS-986231) es un donante de nitroxilo (HNO) de segunda generaciÓn para la insuficiencia cardÍaca.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1620330-72-4
Sample solution is provided at 25 µL, 10mM.
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Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects[1][2].
[1]. Cowart D, et al. A Phase 1 Randomized Study of Single Intravenous Infusions of the Novel Nitroxyl Donor BMS-986231 in Healthy Volunteers. J Clin Pharmacol. 2019 May;59(5):717-730. [2]. Felker GM, et al. Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure. Eur J Heart Fail. 2019 Aug;21(8):1022-1031.
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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