CRT 0105950 |
| Catalog No.GC50404 |
CRT 0105950 es un potente inhibidor de LIMK, con IC50 de 0,3 nM y 1 nM para LIMK1 y LIMK2 respectivamente. CRT 0105950 se puede utilizar para la investigación del cáncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1661845-86-8
Sample solution is provided at 25 µL, 10mM.
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Potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.
Charles et al (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 58 8309 PMID:26356364 |Mardilovich et al (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 6 38469 PMID:26540348
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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