[D-p-Cl-Phe6,Leu17]-VIP TFA |
| Catalog No.GC61773 |
[D-p-Cl-Phe6,Leu17]-VIP TFA es un antagonista competitivo y selectivo del receptor del péptido intestinal vasoactivo (VIP), con una IC50 de 125,8 nM.
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![[D-p-Cl-Phe6,Leu17]-VIP TFA Chemical Structure](/media/struct/GC6/GC61773.png "[D-p-Cl-Phe6,Leu17]-VIP TFA Chemical Structure")
Sample solution is provided at 25 µL, 10mM.
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[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors[1][2][3].
[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86. [2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7. [3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.
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