Docosanedioic acid |
| Catalog No.GC64199 |
El Ácido docosanodioico es un conector ADC no escindible que se utiliza en la sÍntesis de conjugados de anticuerpo-fÁrmaco (ADC). El Ácido docosanodioico también es un conector PROTAC basado en una cadena de alquilo que se puede usar en la sÍntesis de PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 505-56-6
Sample solution is provided at 25 µL, 10mM.
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Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
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