Dopamine HCl (Synonyms: DA, KW 3160, 3-hydroxy Tyramine) |
| Catalog No.GC11028 |
Dopamine D1-5 receptors agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 62-31-7
Sample solution is provided at 25 µL, 10mM.
GlpBio Products Cited In Reputable Papers
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Product Documents
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
- Purity: >98.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Protocol
| Cell experiment [1]: | |
|
Cell lines |
Strial marginal cells |
|
Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
|
Reacting condition |
10 mM |
|
Applications |
In untreated normal strial marginal cells, the reaction product of Na-KATPase could be detectable. However, it became almost completely undetectable after an in vitro treatment with 10 mM Dopamine HCl. These results suggested that Dopamine HCl directly inhibited the Na-KATPase activity of strial marginal cells which might express dopamine receptors. |
| Animal experiment [2]: | |
|
Animal models |
SD rats |
|
Dosage form |
100 mg/kg; i.p. |
|
Applications |
In SD rats, Dopamine HCl treatment for 15 mins did not cause any reduction in degree of catatonia. The maximum score of Dopamine HCl treatment after 150 mins was only 3.5. It was suggested that Dopamine HCl did not cross the blood brain barrier and therefore, could not exert significant effect on drug-induced catatonia. |
|
Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
|
References: [1]. Kanoh N, Ogasawara H, Mohri D, Fukazawa K, Sakagami M. Cytochemical effects of in vitro dopamine treatment on the Na-KATPase activity in strial marginal cells. Acta Otolaryngol. 1996 Nov;116(6):824-7. [2]. Jain NK, Rana AC, Jain SK. Brain drug delivery system bearing dopamine hydrochloride for effective management of parkinsonism. Drug Dev Ind Pharm. 1998 Jul;24(7):671-5. |
|
| Cas No. | 62-31-7 | SDF | |
| Sinónimos | DA, KW 3160, 3-hydroxy Tyramine | ||
| Chemical Name | 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride | ||
| Canonical SMILES | C1=CC(=C(C=C1CCN)O)O.Cl | ||
| Formula | C8H11NO2.HCl | M.Wt | 189.64 |
| Solubility | DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 1 mg/mL,PBS (pH 7.2): 5 mg/mL | Storage | Store at RT,protect from light, stored under nitrogen |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
Complete Stock Solution Preparation Table
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.2731 mL | 26.3657 mL | 52.7315 mL |
| 5 mM | 1.0546 mL | 5.2731 mL | 10.5463 mL |
| 10 mM | 0.5273 mL | 2.6366 mL | 5.2731 mL |
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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Reseñas
Average Rating: 5 ★★★★★ (Based on Reviews and 3 reference(s) in Google Scholar.)
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