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Eliglustat (hemitartrate) (Synonyms: Genz-112638)

Catalog No.GC43595

Eliglustat (hemitartrato) es un inhibidor de la glucocerebrósido sintasa específico, potente y activo por vía oral con una IC50 de 24 nM.

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Eliglustat (hemitartrate) Chemical Structure

Cas No.: 928659-70-5

Tamaño Precio Disponibilidad Cantidad
1mg
21,00 $
Disponible
5mg
95,00 $
Disponible
10mg
140,00 $
Disponible
25mg
366,00 $
Disponible

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Products

Eliglustat is a potent and selective inhibitor of glucosylceramide synthase with an IC50 value of 40 nM for the reduction of glucosylceramide synthesis in K562 cells. Inhibition of glucosylceramide synthase, the rate-limiting enzyme in glycosphingolipid synthesis, also reduces production of cell surface gangliosides GM1 and GM3 on K562 and B16/F10 cells, with IC50 values of 24 and 29 nM, respectively. Eliglustat is specific to glucosylceramide synthase over similar enzymes, having minimal activity (IC50 = >10 μM) at α-glucosidase I and II, lysosomal glucocerebrosidase (GBA1), non-lysosomal glucosylceramidase (GBA2), sucrase, and maltase. In vivo, eliglustat induces a dose-dependent decrease in glucosylceramide accumulation in the liver and lungs of D409V/null mice, a model of Gaucher disease. It also prevents further glucosylceramide accumulation if administered after liver and lung deposits have been established.

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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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