Copeptin (human) |
Catalog No.GA21279
One-Click Copy Product Info
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Copeptin (human) es un péptido compuesto por 39 aminoácidos que se produce principalmente en las neuronas paraventriculares y el núcleo supraóptico del hipotálamo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 78362-34-2
Sample solution is provided at 25 µL, 10mM.
Copeptin (human) es un péptido compuesto por 39 aminoácidos que se produce principalmente en las neuronas paraventriculares y el núcleo supraóptico del hipotálamo[1].
Copeptin puede ayudar en el plegamiento de la vasopresina durante su transporte. La vasopresina tiene un efecto antidiurético directo sobre los riñones y también provoca la constricción de los vasos sanguíneos periféricos. Copeptin puede ser utilizado como un sustituto de la vasopresina en pruebas clínicas[2-4].
In vivo, en el análisis de la anafilaxia sistémica, la temperatura corporal del grupo modelo (Compuesto 48/80) fue significativamente más baja que la del grupo control. El Compuesto 48/80 indujo un aumento en las concentraciones séricas de HIS, TNF-α e IL-8[8]. La degranulación de MC inducida por el Compuesto 48/80 produjo efectos anticonvulsivos contra las convulsiones epilépticas inducidas por PTZ al extender el tiempo de inicio tanto de las sacudidas mioclónicas como de las convulsiones tónico-clónicas generalizadas, y al acortar la duración de las convulsiones tónico-clónicas generalizadas[9].
References:
[1]. Baranowska B, Kochanowski J. Copeptin - a new diagnostic and prognostic biomarker in neurological and cardiovascular diseases. Neuro Endocrinol Lett. 2019 Dec;40(5):207-214. PMID: 32112544.
[2]. Balanescu S, Kopp P, Gaskill MB, Morgenthaler NG, Schindler C, Rutishauser J. Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States. J Clin Endocrinol Metab. 2011 Apr;96(4):1046-52. doi: 10.1210/jc.2010-2499. Epub 2011 Feb 2. PMID: 21289257.
[3]. Morgenthaler NG, Struck J, Alonso C, Bergmann A. Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 2006 Jan;52(1):112-9. doi: 10.1373/clinchem.2005.060038. Epub 2005 Nov 3. PMID: 16269513.
[4]. Christ-Crain M. Vasopressin and Copeptin in health and disease. Rev Endocr Metab Disord. 2019 Sep;20(3):283-294. doi: 10.1007/s11154-019-09509-9. PMID: 31656992.
| Cas No. | 78362-34-2 | SDF | |
| Formula | C177H279N49O58 | M.Wt | 4021.46 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 248.7 μL | 1.2433 mL | 2.4867 mL |
| 5 mM | 49.7 μL | 248.7 μL | 497.3 μL |
| 10 mM | 24.9 μL | 124.3 μL | 248.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)