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CDK4/6-IN-3

Catalog No.GC35634

CDK4/6-IN-3 es un inhibidor de CDK4/CDK6 que penetra en el cerebro con Kis de <0,3 nM y 2,2 nM, respectivamente. CDK4/6-IN-3 inhibe CDK1 con una Ki de 110 nM. CDK4/6-IN-3 se puede utilizar para el tratamiento del glioblastoma.

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CDK4/6-IN-3 Chemical Structure

Cas No.: 2366237-37-6

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Sample solution is provided at 25 µL, 10mM.

Description of CDK4/6-IN-3

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma[1]. CDK4|0.3 nM (Ki)|CDK6|2.2 nM (Ki)|CDK1|110 nM (Ki)

CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively[1].

[1]. Bronner SM, et al. Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2294-2301.

Chemical Properties of CDK4/6-IN-3

Cas No. 2366237-37-6 SDF
Canonical SMILES FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5
Formula C25H31FN8 M.Wt 462.57
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CDK4/6-IN-3

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1 mg 5 mg 10 mg
1 mM 2.1618 mL 10.8092 mL 21.6183 mL
5 mM 0.4324 mL 2.1618 mL 4.3237 mL
10 mM 0.2162 mL 1.0809 mL 2.1618 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 25 reference(s) in Google Scholar.)

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